• Is there a treatment to improve my Peyronie's curved penis?

    My pain and scar are gone.   However the curvature remains.  Is there a treatment to improve the curvature?  Thanks.

    Greetings,

    I am happy for your apparent progress over Peyronie’s disease, although I think you are assuming too much. 

    When you ask this kind of question it tells me that you think of your scar and penis curvature as two separate things.  That is not the case.  The scar and curvature are directly related; the scar is causing the curvature, and without the scar you would not be bent.    The very best treatment, and the one that makes most sense to improve your curvature is to get rid of the cause.  In this case, the treatment to improve the curvature is to get rid of your Peyronie’s scar.  

    While I am sure you are correct that you have noticed reduction of your scar, and perhps you are not even able to find your PD scar any longer, in order for your shaft to still display a curvature there still must be some remaining scar material present within the tunica albuginea.   Sometimes the scar that remains is so greatly reduced or perhaps deeper than you can easily locate, but something must be causing the penile deformity that you still exhibit.   If you did not have some Peyronie’s plaque or scar still in the penis, there would be no explanation for the curvature. 

    I suggest you stay on your treatment plan to get rid of your bent penis.  Perhaps vary your treatment a bit while still following the basic outline that brought you the significant reduction of the scar, so that you can totally eliminate the remainder of it and completely reverse your curvature. 

    If you need help modifying your current plan to clean up the last part of your scar please send me the complete details of your current Peyronie’s treatment plan and i will be happy to make a few suggestions to improve what you are doing.  TRH

    How do I treat Peyronie's disease?

    Within the last two months I noticed that my penis is started bending to the left. I was taking an anti inflammatory for back pain and I’m wondering if the med caused the problem, my penis seems somewhat shorter as well, what can I do to rectify the problem. Richard

    Greetings Richard,

    The first thing you should do is get yourself checked out by a urologist to determine if you have Peyronie’s disease.

    If it happens that you do have Peyronie’s disease you will want to begin a conservative course of care to help your body heal and repair the infiltration of excess collagen in the deep tissue of the shaft. It is this mass of internal scar tissue that is causing your bend to the left. It might appear to be a small point of differentiation, but in Peyronie’s disease the actual problem is the internal collection of collagen under the skin of the shaft that causes distortion of an erection, as well as loss of length and girth, and not the penile curvature; the penile curvature would not exist if it were not for the presence of abnormal deposit of collagen.

    I would have to know the name of the medication to know if it is a possible cause of your current situation.

    For treatment options, please go to the home page of the PDI website and click on the several links that give helpful information about what you can do to help your body heal and repair PD. TRH

    Would you like me to send you pictures of Peyronie's disease?

    Dr. Herazy,

    I am not concerned with sex right now and I have no pain, except I have depression from my Peyronie's disease.

    It seems I have only two problems. 1) a failure in the integrity of the wall of my penis on the left side. This is at a specific point rather than so much at a curve, even though that is there also when it is more erect. My penis doubles over to the left because of the failure in the shaft wall when not erect. 2) When erect my penis wants to hug the trunk of my body towards the left side.

    Would you like me to send you pictures?

     

    Greetings,

    it is very common for men with Peyronie's disease to feel depressed for a variety of reasons.   For many men this depression arises from the (false) idea there is little you can do to help yourself with your Peyronie's disease and that your life will never be the same.  I suggest you begin spending more time reading and studying the PDI website to overcome this feeling of helplessness that seems to come from the idea that no drug has been found to help PD.  You need to know that the body reverses and corrects PD in a fair number of cases, and for this reason your energy should be focused on increasing and supporting your natural ability to overcome your PD.   Once you understand there is a lot you can do to increase your odds for self-repair and learn more about Peyronie's disease you will feel less scared and depressed.   Once you begin to actually do something to improve your physical condition you will feel empowered and in control of you situation.

    There is a great technique I use to help men with their depression, called EFT.   Please go to the PDI website to the page about using EFT for distressing emotional states.  I have worked with many PD men using this technique and the results are often rapid and gratifying. Contact me directly for an EFT session when you are ready to feel better. 

    What you describe as a failure of the integrity of the wall of the wall of the penis on your left side is not at all uncommon for men with PD.  This is commonly called a ding, dent,, hinge or pivot.  It can be caused in one of two ways, or a combination of both.  The first is by the abnormal internal tissue tension or pulling from within the shaft by the fibrous PD scar located in the tunica albuginea.  The second is by leaky veins within the shaft that do not close completely because the presence of the PD scar.  You can think of the PD scar acting almost like someone putting his foot in the doorway and preventing door from closing.  In PD the scar prevents the veins from closing, thus no pressure is built up within the shaft.  Without trapping of blood in the shaft the needed hydraulic pressure never develops to create a completely strong erection.  This can happen in just one small area of the shaft that creates the small dent in the side of the penis.   

    Your left leaning erection is probably related to both the scar and weak erection on the left side of the shaft. 

    There is not any need to send pictures at this time, since PD treatment is not based on the distortion or curve of the shaft.  Treatment is guided by the size, shape, density and surface features of the PD scars that create the distortion.   You must develop an exact knowledge of these characteristics in order to help your PD.   Once you reduce your scars, you will improve the distortion pattern that  bothers you so much.  This physical improvement will greatly help your sense of depression. 

    So, i suggest you get busy.  Please get started with a reasonable Peyronies treatment plan that you can find on the PDI website.   If you need help with this, please let me know.  TRH 

    Change Peyronie’s Treatment Dosage

    How to change Peyronie’s treatment

    Starting Peyronies treatment dosage can be easy if you start by taking therapy products at the manufacturer’s suggested rate – perhaps for the first 14-21 days.  If this dosage causes a change in the size, shape, density and surface qualities of your scar(s), then that simple and small dosage is adequate to provide you with the help you need to eliminate your Peyronie’s disease scar formation.   
     
    This is a list of all therapy products available through Peyronie’s Disease Institute and Online Natural Healthcare LLC with the manufacturers’ suggested dosage:
    1.     Vitamin E Factor 400/400 (60) – 1 or 2/day – with food
    2.     Maxi-Gamma E (60) – 1/day – with food
    3.     Unique E (180) – 1 or 2/day – with food
    4.     Natural C 1 gram (100) or (250) – 1 or 2/day – with food
    5.     Ascorbplex (90) or (180) – 1 or 2/day – with food
    6.     Fundamental Sulfur (100) – 3/day, taken between meals, or if upset occurs, – with meals
    7.     Acetyl-L-carnitine (60) – 1/day – with food
    8.     PABA (100) – 1 or 2 daily – 1/day – with food
    9.     Quercetin Bromelain ((100) – 1-8/day – between meals 
    10. Fibrozym (100) or (200) – 2 tablets, three times a day – between meals
    11. Nattokinase 1500 (120) – 2 tablets, two times a day – between meals
    12. Neprinol (90) or (300) – 1-4 capsules with 8 0z of water – between meals
    13. Scar-X  (1 oz) – 10 drops three time a day – between meals
    14. PMD DMSO Gel (4 oz) – 1-3 times a day, depending on skin tolerance
    15. Super CD Serum (1 oz) – applied to skin before PMD DMSO
    16. Unique-E Vitamin E oil (1 oz) – applied to skin before PMD DMSO
    17. HJG and KBG Honso herbs – 1-3/day
    18. Genesen Pointers – used 15 minutes or longer, daily if desired
    19. Massage and Exercise instructions – performed 2-4 times a week
    20. Gentle Manual Penis Stretching Method © instructions – used 15 minutes or longer, daily if desired
    21. Prosta-Support (120) – 4/day – with meals
    22. Omega T – 1 or 2 daily – with meals 
     
    Dosage usually increases as care continues.  Later intake of therapy is often increased in an effort to determine what dosage is needed to make the Peyronie’s plaque respond in a desired way.   Time and scar response eventually determine dosage.  

    Peyronie's treatment dosage example

    Let us say that you decide you will take PABA at a dose of 2/day. After doing this for a reasonable time – maybe 10-14 days – you do not notice any change in your plaque or scar at the 2/day dose. In this case you probably should consider increasing dosage until your scar responds to your therapy.  The usual method is to simply increase the dosage by one capsule or pill to the total every few weeks until you notice change in the size, shape, density or surface features of the scar.  

    The process is made more complicated by the fact that you should be taking multiple therapies, but that is necessary to achieve results.

    Peyronies dosage determined by scar response

    To know exactly how to modify your dosage it is necessary to compare the size, shape, density and surface features of your scar from the onset of treatment. This critical information enables you to recognize positive changes when they occur. If you do not know how to determine and record the size, shape, density and surface features of your scar you will have to refer to chapter 4 of the “Peyronie’s Disease Handbook” to learn about scar measurement.   

    All dosage increase is done slowly and carefully over a period of time to allow the body the opportunity to respond to a favorable change in therapy. If the dosage is changed too rapidly or too often it will not be possible to determine what factor caused a favorable response.  If you develop any unusual symptoms or change in body behavior or appearance while increasing dosage, simply stop taking the product for 48 hours after that problem/symptom disappears. Restart after 48 hours or when the new symptoms clear up, using the next lower dose.  From this point forward, once again begin the process of increasing dosage to promote favorable scar change. After reaching a higher dose at which changes are noted in the scar, remain at that dosage level for a few weeks.  Your correct dose is discovered by accompanying improvement in scar size, shape, density or surface quality.

    Discuss your PD therapy plan with your family doctor or urologist so he/she is fully aware of what natural Peyronie’s treatment you are following.  You should consider this discussion about dosage strategy after getting final approval from your doctor. 

    When Peyronie’s Scar Not Easily Located

    Peyronie’s plaque

    If you are going to be in charge of your therapy plan, you must know where your Peyronie’s plaque or scar is located.  Even though it is not always easy or obvious, it is essential to Peyronie’s disease treatment because our method is to use “scar behavior” as a guide – a bench mark – a barometer – to judge effectiveness  of care.  Scar behavior is not a matter of curiosity; you MUST know about the scar in as great detail as possible to know if you are making actual progress or not.  If you do not know if there is a change in the size, shape, density or surface features of your scar during treatment, then you are guessing – and shame on you because your results will not be as good as if you actually knew what was going on down there.

    Before I go into this subject in some detail, I must remind you that the Peyronies scar is best located while the penis is soft or flaccid – meaning not erect.  This will be true 99% of the time, so don’t bother to look unless you are flaccid.

    Peyronies scars or plaques can be extremely variable in most all aspects.  For example, while some men have an obvious scar, others could not find one if their life depended on it.   Often, when a scar is not found, but there is still pain and bending or any kind of recent penile distortion, a diagnosis of Peyronie’s disease is still made.  This diagnosis can be accurately made because the scar that is causing the pain or bending is either:

    1. So small – it cannot be found

    2. So very soft – it blends into the other tissue and cannot be detected

    3. So deep – it cannot be reached or felt easily

    4. So large and flat – that the edges are not easily determined, almost like trying to find the edge of a roll of plastic wrap.  When it is a large scar – as many of them are – it is something that is so close to you that you do not see it because you are looking far away and cannot see what is under your nose

    5.  The doctor’s lack of ability, experience or concern when he does the examination – that he simply misses what is actually there if he was better at this kind of thing – yes, I know, it is difficult to imagine but it is true.

    When a scar is never found it is because of a combination of two or more of these factors – deep and small, or soft, large and flat, or deep, soft and doctor error, and so on.  From my experience with those who have an extremely difficult time locating their scar, it seems that #4 (so large and flat) is often an issue.  Keep this in mind when you search your personal  landscape while trying to locate your scar.

    Finding your Peyronie’s plaque

    Ultimately, if you have Peyronie’s disease you must begin the search with the attitude the scar is there, and only waiting to be found.  Do not start with a negative attitude; you want to have a sense of high anticipation that it will be found within the next few seconds – this will help keep your senses alert.   You should use as many different tactics as you can to find your scar(s) because having a good knowledge of your scar situation will help your treatment effort.

    Hint:  Try to think in terms of your scar being much larger than you have previously imagined.  Allow yourself to mentally expand the size of the scar you are looking for.  Meaning, if you were looking for a “pea” before, start looking for a “peanut” size structure or even larger.  This changes your methods and your outlook about what you can detect.

    It seems that lately I have many men reporting that their scars are as large as the length of the shaft.  Of these, some are narrow while others are wider. With this in mind, image that your scar is very large.  If you are looking for a pea-sized scar it will prevent you from easily finding something much larger.

    Do not be discouraged if the scar you have is large since it does not seem that the size has much to do with difficulty or time required to eliminate it.  Larger scars can take just as long as smaller scars to treat.

    Different way to approach Peyronie’s scar

    Try this:  forget about finding a “scar.”  Just try to find something – anything – within the mass of erectile tissue that feels unlike the other tissue.  Find something that is unlike the rest of the tissue. When you find it, mark its location with a marker pen of something that will stay on the tissue for a day or two.  Go back each day to that area and re-think what you are feeling.  You are trying to see if it becomes easier to make sense of it.  It could be that you have an unreasonable expectation of what a “scar” should feel like, and you are missing what is really rather obvious only because your expectation is wrong.  Really, how could you know what a Peyronie’s plaque feels like if you have never had to do this before?  It is a common problem.

    Peyronie’s Disease Institute has much success with the methods we present to you.  Just because your doctor could not locate your scar does not mean it is not there.  And it definitely does not mean that you cannot find it, just because he can’t.   As so many men with PD finally come to understand, you must take control of your situation and begin to get well on your own.

    I have worked with hundreds and hundreds of men who wanted Peyronie’s treatment.  Some of these cases were mild and some were severe, some had it just a few months and a few more than 10 years old.  I had a bad Peyronie’s disease problem until I cured my condition using the procedures found on the PDI website.  You will not feel like a victim once you start working to improve your health and immune response against the presence of this foreign tissue.

    What is Peyronie’s Disease?

    Not all definitions of Peyronie’s disease are honest or correct

    Great question, “What is Peyronie’s Disease?”  However, an accurate and honest answer is not always easy to find.  If you are one of the hundreds of new people each day who surf the Internet for a Peyronie’s cure, you need to pay attention to the kind of answer you might run across.

    In my experience it is common to receive an incorrect answer when it is provided by someone who only wants to sell you something, like a magic herb or a manual penis stretcher.  When a salesperson is the source of your information the answer will often minimize Peyronies by oversimplifying the real problem to the point the answer is not truthful.

    The reason that someone will intentionally give you this false information is easy to understand.  If Peyronie’s disease can be made to sound like a simple problem, then a simple solution can be more easily presented to you in a believable way – and the more likely you will buy a product if the problem and solution sound uncomplicated and straightforward.

    The usual short (and false) answer you will see to this question is, “Peyronie’s disease is a curved penis.”  This is almost like saying that Peyronie’s disease is no more complicated than a bent paperclip.  All you have to do is straighten out the paperclip – and we all know how easy that is to do – and you are as good as new.

    What you must understand is that the bent penis of Peyronie’s disease is just a symptom of what is wrong.  The penile curvature is not the problem, it is just a sign of the real problem. What is causing the penis to curve is the actual problem that must be addressed.   Click here to view

    If you have pneumonia, you will probably have a nasty cough. But, it is not correct – or helpful – to say, “Pneumonia is a cough.”   If the problem was presented to you like that, and you believed it, then someone could sell you a cough suppressant as a cure for pneumonia.  You would believe that stopping the cough is all you have to do.  The truth is that the cough is just an outward sign of a deeper problem. To address your pneumonia correctly you must do what is necessary to help your body reduce and remove the lung infection, the inflammatory response that occurs because of an invasion of foreign bacteria, and the cough – and the pneumonia – will no longer be an issue.  The cough is just a sign of the pneumonia, it is not pneumonia – just as a curved penis is a sign of Peyronie’s disease, but it is not the problem. The bent penis is just an outward sign of a Peyronie’s plaque or scar tissue within the tunica albuginea interfering with the normal filling of the corpora cavernosa, resulting in a bent or distorted erection. No amount of penis stretching or mystery herb from Afghanistan will eliminate the PD plaque.

    So, what is Peyronie’s disease?

    Peyronie’s disease is a problem with no known cause and no known medical cure in which the presence of a dense fibrous nodule or band in the tunica albuginea layer of the penis causes a variable degrees of pain, penile distortion during erection, reduced sexual function, and loss of physical size in length and girth.

    If the explanation, “Peyronie’s disease is a bend in the penis” makes you think it is just like a wrinkle in your shirt that can be ironed out – then you are ready to accept the notion that pulling on the bent penis can magically remove that kink.  If it were only that simple and worked that well.

    You will notice that none of the advertisements for the magical herbs or mechanical penis stretchers explain how they work.  The reason there is no explanation is because they do not affect the Peyronie’s plaque, which is at the heart of Peyronie’s disease.

    For additional discussion to the question, “What is Peyronie’s disease?” please go to Peyronie’s disease discussion.

    Peyronie’s Treatment Sensations

    Strange reaction to Peyronies therapy

    Every now and then I get a question about the variety of unusual sensations and reactions that men notice during Peyronie’s treatment, or immediately after, a particular therapy used in Peyronies treatment.  These are the Peyronie’s disease therapies most often associated with this kind of response:

    1. Genesen Acutouch Pointers
    2. Manual stretching method found on the CD
    3. DMSO PMD formula
    4. Super CP Serum copper peptide ointment

    Most often the sensation is described as a “tingling” or “aching” or “electrical” sensation in or near the area of treatment.  It can be felt during or within the hour any of these therapies are applied.  The intensity can be variable from time to time it is felt; sometimes very mild and hardly noticeable, and at other times enough to wake a person from a sound sleep. Sometimes the response occurs each time the treatment is done, and for other men the reaction occurs every now and then at irregular times.

    If you experience this kind of reaction in the area of your Peyronie’s scar, do not become alarmed. It is common and usually signals some good response to your Peyronie’s treatment as changes are occurring in the condition of the scar.

    This is not something that has been studied much in the scientific literature since those researchers prescribing drugs or standard medical procedures for PD do not get the kind of reactions and responses that occur while following the Peyronie’s Disease Institute therapy principles.  They do not report this kind of reaction because they do not make the kind of rapid changes that are seen in men using the PDI protocols.

    Therefore, there is no research that has been done to explain this phenomenon.  It is my theory that these reactions are due to the rapid changes that take place in the tissue in and around the scar material.  During or after a particular Peyronie’s treatment a change may occur in the tension and length of the otherwise contracted scar material of the penis.  These alterations of tension and position of the tissue layers could easily explain the unusual sensations that occur. I find from my own treatment experience, and that of other men who have had improvement in their Peyronie’s disease, that these “moving” or “tingling” or “aching” sensations appear when the scar is undergoing some level of change (improvement).  Many men come to count on the appearance of these changes to herald improvement of their scars from time to time.

    It is most probably NOT just one therapy or just the one product causing this usual sensation.   It is closer to the truth to say that these sensations are the sum total of all the synergistic efforts that are included in your therapy plan. The problem (a good problem) with using so many of these therapies together is that you will never be able to accurately say which one did the most or least for you.   A synergistic Alternative Medicine therapy plan is a group effort, with all therapies making some contribution to whatever happens to you.

    Please email your questions about Peyronie’s disease treatment to this blog.

    Curved Penis and Peyronie’s Disease

    Peyronies bent penis is focus of problem

    While the primary interest of Peyronie’s disease treatment is the internal scar tissue or fibrous  plaque material that causes the distortion or curved penis to develop, it is not the primary interest of the man who has PD.  For him, the most important aspect of Peyronie’s disease is the curved penis that plagues him.  For this reason Peyronies is also known as the “bent nail disease.”

    For those interested in viewing graphic pictures, click curved penis of Peyronie’s disease.

    Peyronie’s disease causes a curved penis when the fibrous tissue of the Peyronie scar or plaque pulls unevenly or causes incomplete filling within the erect penis.  This can vary in degree or severity from man to man.  For this reason the curved penis does not indicate the severity of the Peyronies problem or success of Peyronies disease treatment.  The true success of Peyronies treatment is based on the change that occurs in the Peyronies plaque or scar.  Once the fibrous scar changes, eventual improvement in the curved penis can be expected in time.

    The internal tissue of the healthy penis is flexible and expandable.  This normal tissue is able to allow for a normal erection to develop when blood is trapped inside the organ.

    In Peyronie’s disease some of the tissue is not healthy or flexible and elastic.  Specifically, the deep tissue known as the tunica albuginea is not elastic because it replaced by dense and inelastic fibrous tissue that is called a scar or plaque.   As an erection develops the elastic tissue of the tunica albuginea must stretch and expand evenly on both sides, left and fright, and top and bottom, of the penis.  If this cannot happen because an area of the penis is no longer flexible and expandable, then a curved penis results.

    Peyronie’s disease usually begins with a small nodule or bump that is found on the top or sides of the penis, just immediately below the surface.  A few weeks to several months to a year later, a small fibrous nodule can expand into a larger irregular scar of variable size, shape, density and surface quality.  These scars can be as long as the penis.  Some appear like a collar to go around the shaft.   Some are one large mass, while others appear to be like small isolated islands of fibrous tissue in many areas.   Scars can be so soft or small, with edges so tapered and vague that no scar can be found.  In a case of Peyronie’s disease when no scar or plaque can be found, it is still assumed to exist when a curved penis develops during erection. .

    Normally curved penis

    Most men have a straight erection, but some are born with a penis that curves or bends (usually upward).   Just as fingers on the hand or a nose can display a natural bend, or arms can be of different length on the same person, the penis can be bent without the presence of Peyronies.  Typically, the normally curved penis follows a more gradual and arched design, more like a banana.  In Peyronie’s disease the curved penis is more localized and abrupt, like an angulated bend.

    When the two primary chambers (corpora cavernosa) of the penis are a different diameter or length, the penis will bend when erect.   The penis will appear straight when flaccid, and on erection it will bend.

    This slight penile distortion will not be associated with pain, there will be no trauma in the history, and it will not appear suddenly as does the curved penis of Peyronie’s disease.

    Curved penis affects sexual intercourse

    It is estimated that 75-90% of Peyronie’s disease couples will sooner or later experience a sexual intercourse problem, in regard to either pain or difficult penetration – or both.   The curved penis of is the primary reason sexual penetration is compromised, and it is also the reason for the pain that can be experienced by either – or both – partner. This is especially so in those cases in which the distortion is so severe it is described as “cork screw” or “cane handle.”

    Incomplete filling of the penis with blood during erection can also happen in Peyronies.  This results in an area of the penis, either small or large, that is soft and unable to sustain the rigors of intercourse.  A soft area within an otherwise firm erection presents a weakness and vulnerability of the normally turgid erection.  A weak area of erection can suddenly collapse or buckle during intercourse, causing additional injury to the penile tissue.  This can cause pain, inflammation and additional fibrous infiltration.

    It is a rare Peyronies couple that does not deal with some level of sexual difficulty related to penile distortion and reduced firmness of the erection.  The many physical, emotional and social issues of Peyronie’s disease are complex.  For this reason the reader is referred to “Peyronie’s Disease and Sex” for more information about this complicated area of life with a curved penis.

    Treatment of the curved penis

    It is important to remember that any penile distortion that develops in Peyronie’s disease is not the primary problem of this condition.   A curved penis that appears one night is difficult to ignore, but is only a symptom of the real problem of Peyronie’s disease – the scar. Without the Peyronies scar there would be no curved penis.

    This is the reason I advise men who are undergoing Peyronies treatment to focus on the size, shape, density and surface qualities of the scar or plaque to determine if their Alternative Medicine treatment is being effective.  The curvature can improve or worsen as the scar is reduced.

    A small scar can cause a large bend, just as a large scar can cause no bend at all if it is balanced and symmetrical.   For this reason a curved penis can worsen as the scar is being reduced or eliminated.   Estimating progress or success of a PD therapy plan is difficult .  A man can have many more scars than he is aware of, and they can be larger than can be detected since they are often difficult to locate and often overlap.

    If only one scar is present the curvature problems are direct and easy to understand, although  this is unusual.   However, if multiple scars are present the internal pulling and twisting they cause can be very complicated.   Several scars can interact on many  planes of internal penile tissue.   Any reduction in one or more scar will alter the internal tension and pulling of the tissues, resulting in an altered curvature.  There is no guarantee the curvature will change for the better initially – sometimes it can look worse as the scars become smaller.  This is why I advise to focus all attention to the size, shape, density and surface qualities of the scar while treatment of the Peyronies problem continues.  Realize the curved penis is just a reflection of what is going on with the scar9s) below the surface.

    Do not be discouraged by the curved penis of Peyronie’s disease.  Instead, stay focused on your plan for effective Peyronies treatment.  Learn more about Peyronie’s disease treatment.

    Peyronie’s Plaque or Scar

    Peyronie’s plaque or scar central issue

    The central issue of Peyronie’s disease is the infamous Peyronie’s plaque, also called a scar. Peyronie’s disease typically occurs in men between 40 and 65 years of age, although a range of 16 to 80 years is documented; some experts say it can occur at any age. From personal communication with a particular man, I was told that his own Peyronie’s disease was started after a dog bite to the groin – at the age of 10. Nonetheless, it is most important to recognize that all clinical signs and symptoms of Peyronie’s disease originate from the effects of the plaque upon the internal tissue layers (tunica albuginea) of the penis.

    A developing Peyronie’s plaque appears in response to either micro-trauma to the small blood vessels from a single injury of great force, or multiple injuries of a small force. While there is strong evidence that genetic factors and drug factors also influence the start of PD, it is trauma that is usually considered to be the most likely cause of the Peyronies plaque or scar.

    A Peyronie’s plaque on the cellular level initially consists of fibrin threads deposited in a massive network throughout an area of injury within the tunica albuginea of the penis. Peyronie’s plaques, or scars, later combine the dense threads of fibrin connective tissue with reduced and fragmented elastic connective tissue fibers, as well as excessive amounts of type III collagen material, which happens to be specially inclined to excessive scar development. In about one-third of chronic cases of Peyronie’s disease, calcification of the plaque can occur over time. For more technical information about the Peyronies disease plaque.

    The curvature of the Peyronies penis is due to the fact that scar tissue does not stretch as easily or as fully as healthy normal tissue. The normal tunica albuginea is composed of elastin fibers and collagen, although the site of scar tissue from Peyronie’s disease is composed mostly of collagen. This difference in composition of these two tissues is what causes a bent penis to develop during erection.

    Eventually as one or more Peyronie’s plaques develop into a mass of hardened tissue in the delicate tunica albuginea, it results in variable pain and penile distortion that most often takes the form of a bend or curve; sexual function is often reduced as a result of direct or indirect affects of Peyronie’s disease, also. The penile curvature of Peyronie’s disease is caused by the dense inelastic scar, or plaque, material that shortens the involved side of the tunica albuginea layer that covers the corpora cavernosa of the penis. In approximately one third of patients, the scarring involves either the top or bottom portion of the penis shaft, occasionally both. The lateral sides of the penis can also be affected by Peyronie’s plaque development, if that area experiences injury.

    Peyronie’s plaque not easy to find sometimes

    In some men the Peyronies plaque is easily found on manual examination, in others it is found with difficulty, and in some men no Peyronies plaque is ever located. It can be frustrating to have a wicked penis distortion, and still not be able to locate the Peyronie’s plaque.

    To locate the plaque or scar material a light and inquisitive touch is most effective. Do not be heavy-handed, or press down into the deeper layers to find the Peyronie’s plaque material, because it is found just below the surface of the skin. And, oh yes, you will never directly see the plaque or scar, since it is not on the surface of the skin, but below. Make peace with the Peyronie’s plaque and do not hate it, just determine how to assist your body to remove it.


    To learn about using Alternative Medicine to increase your ability to heal and repair the Peyronie’s plaque, a good place to start is the PDI website, Peyronie’s disease treatment introduction.

    Peyronie's Plaque and Fibrin

    Peyronie’s disease plaque and fibrin

    The tissue changes that occur in Peyronie’s disease are unique in regard to the Peyronie’s plaque that develops.

    In a November 2005 abstract account, Kenneth D. Somers and Dawn M. Dawson, of the Department of Microbiology and Immunology, Eastern Virginia Medical School, Norfolk, Virginia, and Department of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, reported on their findings concerning the tissue changes that occur in Peyronie’s disease.

    To begin this explanation, they remind us that Peyronie’s disease is actually a pathological fibrosis, or a situation in which there is excess fibrin tissue located in a small area to the degree that it becomes a problem for the body. In the case of Peyronie’s disease, this fibrosis also is associated with an excessive deposit of collagen in the same area of the fibrin plaque or scar.

    Although the cause of Peyronie’s disease remains unknown, they tell us, injury or trauma has long been thought to be the inciting event. To determine if this is true, they looked at the cellular structure of the Peyronie’s plaque or scar to get an insight into the cause of this condition.

    Materials and methods they used

    Small samples of plaque tissue was taken from 33 patients with Peyronie’s disease, and control tissue and nodular tissue was taken from the penis of eight patients with Dupuytren’s contracture; both groups of tissue were analyzed for collagen staining, as well as fibrin and elastic fiber structure and distribution.

    Their results

    As a result of this study they found abnormally stained collagen in 97% of the samples, disrupted elastic fibers in 94% and excess fibrin deposition in 95% of the samples. These same findings were not found in the normal scared tunica albuginea of control patients who did not have Peyronie’s disease. The presence of abnormal fibrin accumulation in Peyronies plaque tissue was detected in a special chemical analysis, while this abnormal fibrin was not found in skin tissue samples from the same patients.

    Their conclusions

    Their conclusions from this study is that the fibrin deposits in Peyronies plaque tissue is consistent with the theory that repeated minor injury or single major injury to the tunica albuginea results in fibrin being deposited in the tissue spaces at the site of trauma to start this condition.

    PDI therapy concept

    Peyronie’s Disease Institute has taken the position that it is this excess fibrin deposit within the excess collagen formation that can be safely and easily removed by the use of a battery of systemic enzymes that are specific for foreign fibrin protein in the body. By using natural Peyronie’s disease treatment methods to increase the healing response of the immune system against Peyronie’s disease plaque, it is possible to reverse the abnormal tissue found in the tunica albuginea and therefore eliminate the cause of pain and penile curvature associated with Peyronie’s disease.

    Peyronie's Syndrome

    Peyronie’s disease defies classification

    Technically, Peyronie’s syndrome is not the correct way to refer to Peyronie’s disease.  Actually, calling it Peyronie’s disease is not correct, either, but more on that later.

    First, the term Peyronies syndrome.   A syndrome refers to a group of several essential and clearly recognizable clinical signs, symptoms and characteristics of a health problem that often occur in association or together.  In the situation in which a syndrome occurs, the presence of one feature, sign or symptom would alert a doctor to the possibility a particular syndrome was present, so he/she would automatically look for other features, signs and symptoms that normally occur with it.  If those additional findings are detected, then  a diagnosis of that syndrome could be made.

    Peyronie’s syndrome is not a valid term because the characteristic Peyronies symptoms are actually too few, and they do not usually form a tightly bound set of features that suggest this particular health problem. The few symptoms and signs associated with PD are actually vague by usual medical standards. Since there are typically only three such standard features or clues associated with Peyronie’s disease  (penis pain, distorted or curved penis, and the common Peyronie’s plaque or scar), this set of presenting characteristics is not large enough or strongly suggestive of the condition, hence syndrome is not a good term to use.

    Peyronie’s syndrome is not a disease, either

    Then we come to the term Peyronie’s disease, which is not all that accurate either.  A disease refers to any condition that causes extreme pain, significant organ or system dysfunction, social problems, and even death, and is usually acquired through direct or indirect transmission or communication from one person to another.  Of course, there are many definitions and ways of looking at what constitutes a disease, but that is generally acceptable in most cases.

    Since Peyronie’s disease seldom causes extreme pain, and sometimes no pain at all, it does not fulfill that requirement.   Since the genitourinary system of which the penis is only a part continues to function, and the penis continues to carry urine and oftentimes is still capable to function sexually, it does not fulfill the requirement of loss of function.  While having a bent penis plays havoc with the man who has it, and the woman or women he is sexually active, it does not affect society as a whole, the way actual diseases like the flu or measles, syphilis, tuberculosis or alcoholism do.  Peyronie’s disease is not fatal, except to some couple’s sex life, so it also does not fulfill that part of the requirement.  And lastly, this problem is not communicated or transmitted from one person to the next; you cannot catch Peyronies.

    When referring to Peyronie’s disease it is more accurate and fair to use other terms like “condition,” or the more descriptive terms that follow in this list.  These are more clinically accurate names that have been collected and were taken from the PDI website:

    1. Indurato penis plastica
    2. Chronic cavernositis
    3. Fibrous sclerosis of the penis
    4. Fibrous cavernositis
    5. Fibrous plaques of the penis
    6. Penile fibrosis
    7. Penile fibromatosis
    8. Penile induration

    This list of descriptive terms was taken from the PDI website where the basics of Peyronie’s disease are discussed at length.  If you wish to learn more about this condition, called Peyronie’s disease, please review this additional information.  But whatever you do, do not call it Peyronie’s syndrome, OK?

    Peyronie's Plaque

    Peyronie’s disease plaque or scar

    There is much confusion and lack of information concerning Peyronie’s disease, especially the elusive Peyronie’s plaque or scar .

    It is truly amazing that for a male health problem that according to some surveys affects up to nine percent of the adult population, practically no man ever hears about this problem until the day he is given the diagnosis of Peyronie’s disease.  It is no wonder that no one has ever heard of a Peyronies plaque until he has one.  It is this shock – that a “mystery” condition that comes out of the blue, a condition for which there is no known cause and no known Peyronie’s cure can suddenly wreck a man’s life – that contributes to the lack of information about Peyronies.  While feeling totally confused and shocked upon first hearing about the Peyronie’s plaque or scar that accompanies it, prevents a man from asking all the standard questions and retaining the information he is told when he receives this diagnosis.

    With such bad news pouring into his ears, and so many questions rolling around in this brain, it is no wonder that a man can leave his doctors office and not remember much of what he is told  about Peyronies.

    In addition to this shock of learning he has Peyronies, most medical doctors do not like to manage cases of Peyronie’s disease, and therefore do a bad job of it, further adding to the common situation in which a man will not understand the basics of this problem – like the Peyronies plaque.

    We all know Peyronies disease is called the “doctor’s nightmare” because of the problems associated with dealing with men who have this problem.  With no known cause or cure, the doctor comes off looking like a dummy for not having more clear information or help for his newly diagnosed Peyronies patient.  Adding to the negative atmosphere for the doctor in dealing with a Peyronies patient, the doctor also knows there will be hard feelings that will arise later when the PD patient develops additional penile curvature, reduced sexual performance, and frequent marital problems.  All of this happens while the doctor can only stand by as his Peyronies patient deteriorates over time. The doctor is often held responsible for these problems since he did not offer any help to his patient.  None of this is fair, but this is how it happens.   For these reasons many doctors try to get a man out of the office as quickly as possible, and often without sufficient time to ask questions or adequate explanations to prepare a man for the future.

    In this atmosphere of minimum time and minimum information, the shocked Peyronies patient does not understand or recall basic facts about Peyronie’s disease.  For example, the fundamental problem of PD pivots around the presence of one or more masses of fibrous material located within the covering of the substance of the penile shaft, called a Peyronies plaque or scar. Many times a man who has had PD for many years will no absolutely nothing about his  Peyronie’s plaque.

    Peyronies Plaque is elusive

    Another common situation exists in which the doctor cannot find a Peyronie’s plaque, and neither can the man who owns it.  Each week I receive several emails asking me, “Since my doctor examined me and could not find anything, and I cannot see a scar, do you think I really have Peyronie’s disease?”

    The fat is, there is never an EXTERNAL scar or plaque in Peyronie’s disease; it is always an internal mass that conveniently is known as a scar, but is not a scar in the usual sense.  PD “scars” or plaques are quite variable.  Some men have an obvious scar and others cannot find one if their life depended on it.   Ultimately, it is there and you should try as many different tactics as you can to find your scar(s) because having a good knowledge of your scar situation will help your treatment effort.  Hint:  Try to think in terms of your scar being much larger than you have previously imagined, so mentally expand the size of the scar that you are looking for.  Meaning, if you were looking for a “pea” before, start looking for a “postage stamp” or a “thumb nail” size structure.  This information should change your methods and what you can detect when trying to locate your Peyronies plaque.

    A Peyronie’s plaque or scar can be quiet variable; some men have an obvious plaque and others cannot find one if their life depended on it.   Often, when a scar is not found, but there is still pain and bending or any kind of recent penile distortion, a diagnosis of PD is still made.  This is so, because it is the Peyronies plaque or scar that is causing the pain or bending is either:

    1. So small – it cannot be found

    2. So very soft – it blends into the other tissue and cannot be detected

    3. So deep – it cannot be reached easily, especially during erection

    4. So large and flat – that the edges are not determined, almost like something that is so close to you that you do not see it because you are looking far away

    5.  The doctor’s lack of ability, experience or concern when he does the examination – that he simply misses what is actually there if he was better at this kind of thing – yes, I know, it is difficult to imagine but it is true.

    Usually, when a scar is NEVER found it is because of a combination of two or more of these factors – deep and small, or soft, large and flat, or deep, soft and doctor error, and so on.

    I often suggest that men try this:  forget about finding a “scar.”  Just try to find something – anything – within the mass of erectile tissue that does not feel like the other tissue pf the shaft.  Find something that is unlike the rest of the tissue.  When you find it, mark its location with a marker pen of something that will stay on the tissue for a day or two.  Go back each day to that area and re-think what you are feeling.  You are trying to determine if it becomes easier to make sense of it.  It could be that you have an unreasonable expectation of what a “scar” should feel like, and you are missing what is really rather obvious.  Really, how could you know what a Peyronie’s plaque feels like if you have never had to do this before?  It is a common problem.

    Let me know your experiences and problems in locating your Peyronie’s plaque. Take this chance to tell others your experiences and problems with this elusive tissue.

    Peyronie's desease

    Peyronie’s disease misspelled commonly – Peyronie’s desease

    Peyronies disease is commonly misspelled as Peyronie’s desease. There is so much basic information that people lack concerning this problem that even the name is confusing to some. Other than Peyronies desease, the most common way I find people referring to this problem is to shorten the name and avoid the apostrophe and just call it peyronies, without even capitalizing the first letter, and peyronie, by dropping the final letter altogether.

    Just as a basic review, it is important to know that Peyronie’s disease is most well known for the Peyronie’s plaque or deposit of fibrous tissue (also called a scar) that develops within the deeper layers of tissue of the penis.  This fibrous material often, but not always, will cause a Peyronie’s curved penis and pain in the penis.

    This Peyronie’s plaque or scar material itself is benign, meaning it is always non-cancerous. It is a common fear among men when first learning they have Peyronies desease to wonder if it could develop later to become something more serious.  This is not the case.  You can rest assured that Peyronie’s disease will not develop or progress into a worse or life-threatening condition – Peyronie’s disease is bad enough.  It does not need any help to make a person’s life miserable all on its own.

    Peyronie’s disease typically occurs in men around their mid-50s, however,  even teenagers can develop it.  The cause of Peyronie’s disease and its natural progression or development are not well understood because the course of the disease is so variable.  In my experience while researching Peyronie’s desease and in discussion with hundred’s of men every years concerning all aspects of this problem, it is rare to find two cases that share a remotely similar history or course; each case is unique in small and large ways.  This great variability is what makes this condition so difficult to diagnose, treat, and live with.  While many researchers believe the Peyronie’s plaque often develops in response to some type of trauma, either minor or significant, that results in localized bleeding within the internal tissue of the penis.

    Sexual problems associated with Peyronie’s desease can also be variable, since there are such physical and emotional differences among couples, to say nothing of the variability of sociological factors that also can disrupt a couple’s physical and a stressful emotional relationship. The goal of Alternative Medicine Peyronie’s treatment is to keep a man and woman who deal with this problem as happy and whole as possible.   Peyronie’s disease surely affects all the people whose life it enters, even if you happen to spell it Peyronie’s desease.

    Cause of Peyronie's disease

    How Peyronie’s disease starts

    As anyone who has the problem knows, the cause of Peyronie’s disease is not well understood.  However, any research topics that shed light on this basic question are of great interest to men who have Peyronie’s disease.

    Perhaps a good question to start with is, what causes the erect penis to bend in a case of Peyronie’s disease?  The answer lies in the function of the corpora cavernosa functions in the mechanism to produce an erection. There are actually two corpora cavernosa, laying side by side like two cigar shaped, paired balloon-like chambers that must be filled with blood to create an erection. Their connective tissue wall, the tunica albuginea, offers resistance and rigidity when it is stretched to its maximum.  The tunica is elastic to a point, but unlike the thin and flexible wall of a balloon, the tunica albuginea is interlaced with strong connective tissue fibers. These strong fibers do not allow for much expansion, and eventually determine the shape of the erect penis because of their structural rigidity.

    Thus, in a very real and fundamental way, Peyronies disease is a disorder of the tunica albuginea. By producing dense and rigid areas of the tunica, called Peyronie’s plaque or scars, Peyronie’s disease interferes with the full expansion of the tunica. Plaques are either regions of reversible inflammation in early phases of Peyronies, or permanent scars later if the inflammation is severe and continues too long.  Much like a piece of tape placed on the wall of a balloon, the plaque or scar causes uneven filling and expansion of the tunica, and this causes bending  of the column of the corpora cavernosa.

    A basic question is, what causes these plaques to begin?  Microscopic and chemical studies show that plaques represent an early stage of the wound healing process when the tunica is injured. Whatever starts Peyronie’s disease, the problem seems to the inappropriately increase of the normally healthful and proper process of wound repair.  Actually, wound healing may not be the appropriate term in all situations.

    Most likely cause of Peyronie’s disease

    One cause of Peyronies disease is obvious and direct trauma to the erect penis. This trauma can range from sudden and unexpected angulation during sex, to am actual rupture of the corpora cavernosa.  However, the fact is, many men with Peyronies do not recall any such traumatic occurrences.

    Over time, all sexually active men will experience some degree of wear and tear on vulnerable areas of the soft tissue erection mechanism. Both the structural arrangement of the corpora and the inherent elasticity of its connective tissues counteract the strong mechanical stresses created by strong sexual activity.  But when men reach their mid-fifties, fundamental connective tissue elasticity throughout the body, and the penis, is on the decline.   And so, it just so happens that the average for appearance of Peyronies disease is fifty-four.

    Peyronies plaques most often appear along the top surface of the penis. It is this region where the two corpora meet side by side, along the upper edge of the “inflatable I-beam” created during an erection that is most vulnerable to stress induced delamination.  Another word for a layer is a lamina; when layers are disrupted or separated, it is called delamination.

    Autopsy studies in the mid-1990s on men have shown the earliest microscopic changes thought to be early Peyronies disease changes are actually a common finding.   It seems that while many men develop these changes, they will evolve into Peyronies plaques only for a small percentage of cases.

    So what causes the process of normal wear and tear to develop abnormally into the destructive process of wound healing that is called Peyronie’s disease?  There are no clear answers to this question.   However, Peyronies disease is more common in diabetics, as well as men who have gout.  These are two conditions that can have an adverse affect on normal connective tissue healing. It is also more common in the presence of Dupuytren’s contractures. These scars of the fascial covering of the finger tendons in the palm of the hand are thought to be inherited, and may reflect an abnormal tendency toward scar formation in other areas.

    Thus, we see that much is still to be learned about Peyronie’s disease, but as these microscopic tissue clues are unraveled, the mystery of this problem will be advanced, as well as Peyronie’s disease treatment.

    Peyronie's disease treatment with Xiaflex

    Peyronie’s treatment with experimental drug, Xiaflex

    Peyronie’s disease is best known for the plaque, scar or hard lump that causes a curved penis to develop.   Peyronies begins as a localized inflammation, usually as a result of injury of some type. It is currently believed that Peyronie’s disease is caused by vascular trauma or injury to the deeper penis anatomy. Peyronie’s disease is most common in men over 50 years, and the incidence increases with age. This inflammation often progresses to a hardened plaque or scar that reduces flexibility of the tissue of the penis, and results in a bend or distortion during erection due to incomplete filling or restriction of the tissue.  Often, this causes constant pain or pain during erection, and for some men these can prevent sexual intercourse due t physical incompatibility or erectile dysfunction.

    Aside from the physical changes, depression and reduced self-esteem are commonly experienced by men with Peyronie’s disease.

    Peyronie’s disease is most often treated by urologists, even though there are no approved drug therapies for Peyronie’s disease.  Peyronie’s surgery may be an option for some patients although complications such as worsening of the PD distortion can develop, as well as loss of penile length can occur.   Xiaflex, a type of collagen reducing enzyme, or collagenase, has been experimentally injected into the Peyronie’s disease scar or plaque as an in-office procedure. The purpose of injecting Xiaflex into the PD scar is to soften the scar tissue and improve or reduce the curvature of the penis. Further, this is hoped to improve sexual function and eliminate the distressing negative psychosocial aspects of Peyronie’s disease.

    Peyronies Xiaflex trial results

    Sponsored and monitored by BioSpecifics Technologies Corp., licensor of Xiaflex, the 12 month phase II open-label trials of Xiaflex showed limited but promising results.  These research tests were conducted to evaluate the ability of Xiaflex to successfully treat Peyronie’s disease, as well as its compatibility and side effect potential.  In this process clinical success was defined as a baseline change of penile angulation of at least 25 percent.

    Each of the study participants received three injections of Xiaflex, administered on a separate day, and given over seven to ten day period.  Twelve weeks later, each man received a second series of three injections.  Research subjects were evaluated at three, six, and nine months after the Xiaflex injection series.

    The average baseline angulation was 52.8 degrees.  In this study clinical success was achieved at three and six months with 58 percent and 53 percent of patients, respectively.  This would suggest that early success might not last very long or that the improvement to the Peyronie’s disease distortion was temporary.

    In this study there were adverse reactions with Xiaflex that were not described in the general media.  The most common adverse reaction was only reported as a problem at the local administration site that was mild or moderate in severity, non-serious, and resolved in time without medical attention.  No comment was made about worsening of the Peyronie’s disease after the nine month time frame as a direct result of repeated injury to the delicate tunica albuginea tissue from the multiple needle injections of the needle used to deliver the Xiaflex.

    It is the opinion of PDI that for some men these repeated injections could make their Peyronie’s disease condition worse over time.   It might be prudent for the average man to wait until more clinical treatment results are collected and interpreted before considering this treatment approach.

    Peyronie's disease plaque and fibrin

    Tissue changes of Peyronie’s disease are unique

    In a November 2005 abstract account, Kenneth D. Somers and Dawn M. Dawson, of the Department of Microbiology and Immunology, Eastern Virginia Medical School, Norfolk, Virginia, and Department of Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, reported on their findings concerning the tissue changes that occur in Peyronie’s disease.

    To begin this explanation, they remind us Peyronie’s disease is actually a pathological fibrosis, or a situation in which there is excess fibrin tissue located in a small area to the degree that it becomes a problem for the body.  In the case of Peyronie’s disease, this fibrosis also is associated with an excessive deposit of collagen in the same area of the fibrin plaque or scar that results in a curved penis.

    Although the cause of Peyronie’s disease remains unknown, they tell us, injury or trauma has long been thought to be the inciting event. To determine if this is true, they looked at the cellular structure of the Peyronie’s disease plaque or scar to get an insight into the cause of this condition.

    Materials and methods they used

    Small samples of plaque tissue was taken from 33 patients with Peyronie’s disease, and control tissue and nodular tissue was taken from the penis of eight patients with Dupuytren’s contracture; both groups of tissue were analyzed for collagen staining, as well as fibrin and elastic fiber structure and distribution.

    Their results

    As a result of this study they found abnormally stained collagen in 97% of the samples, disrupted elastic fibers in 94% and excess fibrin deposition in 95% of the samples.  These same findings were not found in the normal scared tunica albuginea of control patients who did not have Peyronie’s disease. The presence of abnormal fibrin accumulation in Peyronies plaque tissue was detected in a special chemical analysis, while this abnormal fibrin was not found in skin tissue samples from the same patients.

    Their conclusions

    Their conclusions from this study is that the fibrin deposits in Peyronies plaque tissue is consistent with the theory that repeated minor injury or single major injury to the tunica albuginea results in fibrin being deposited in the tissue spaces at the site of trauma to start this condition.

    Peyronie’s treatment concept

    Peyronie’s Disease Institute has taken the position that it is this excess fibrin deposit within the excess collagen formation that can be safely and easily removed by the use of a battery of systemic enzymes that are specific for foreign fibrin protein in the body.  When combined with other known methods to increase the healing response of the immune system against Peyronie’s disease plaque, it is possible to reverse the abnormal tissue found in the tunica albuginea and therefore eliminate the cause of pain and penile curvature associated with Peyronie’s disease.

    Peyronie’s Disease Treatment: Early Changes to Look For

    Early signs of response to Peyronie’s treatment

    This post is about an interesting question I am asked from time to time about Peyronie’s disease treatment.  I thought it might be of interest to you.  The question is asked something like this, “When people finally get some positive changes in their Peyronie’s disease, how does it usually show up?  What usually happens first?  I want to know what I can expect, although I know we are all different.”

    Well, usually – not always – as a man continues with a sufficiently large and aggressively applied Peyronie’s disease treatment plan from PDI, he will notice at first some small and TEMPORARY changes in the size and density of his scar.  The temporary nature of the change does not last long.  As treatment continues the changes and improvement become permanent.  Usually the scar itself will change before there is a noticeable change in the penis curvature or his ability to develop an erection.  This scar change will take place maybe during months 2-6 of the treatment cycle, although I have worked with men who see changes in the scar after just a few weeks of a PDI plan.  This fast response is the exception and not the rule, so do not plan on that kind of response although it does happen.

    The initial and temporary improvement in the Peyronies plaque or scar will not last very long, maybe just a few days or so, and then it will often go back to how it was before – maybe even worse.  I wish I could say why this happens – it just does. Soon a pattern will develop in which there is improvement, regression, improvement, regression, back and forth, etc.  What happens over time is that you will notice that the amount of improvement will be greater than the regression, and the improvement will last longer than the regression.  You will likely see the pattern shifting slowly in favor of improvement – it will last longer and it will be greater than the regression.  Just like the stock market – it goes up and it goes down – but the general trend and pattern is that it slowly comes gets better.  This is how I have seen most every case of Peyronie’s disease improve.

    Just as the Peyronie’s plaque changes, a little while later it is common to see a change in the curvature. The initial change in the penis curvature is not always improvement, however.  My curve worsened just after my scar showed some real strong progress for the first time.  I kept in mind that the Peyronies plaque was getting better, so I did not let the change in the curve upset me.  I kept working to reduce the scars I had and in time the curve I had also eventually improved.

    Peyronie’s plaque and pick-up-sticks

    Ever play “pick-up-sticks” as a kid?   With the complex interplay of sticks lying across each other, removing one stick makes three or four other sticks shift a bit.  I think the same happens in Peyronie’s disease.

    How many plaques or scars do you have?  If more than one, then the dynamics are made even more complicated.  If you have only one scar (kind of unusual) then you have one scar that could be influencing 2-3-4 different planes of connective tissue within the corpora cavernosa of the penis that it is attached to.  It is not difficult to understand that if a part of a scar is changing, or one of four scars is disappearing, it could cause alteration of the tensions and angles of pull – as the scar is INCREASING or DECREASING in size – that could cause a change in the curve – to make it INITIALLY better or worse.  So in this sense, an increase in your curve is only seen as a bad thing if you know FOR A FACT that your scar(s) are increasing in size, shape or density. Over time, as the plaque continues to soften and reduce in size, and as the internal pull and tension created by these plaque begins to normalize, the curve should begin to straighten.  Continue monitoring yourself as you work aggressively, and you should see this positive pattern of recovery play out for you.

    A worsening of the curve is acceptable if the plaque is improving.  As far as treating your condition and monitoring progress, the condition of the Peyronie’s plaque is far more important to monitor than a curved penis; plaque changes size, shape and density characteristics, and even seem to move, and so the plaque or scar tissue exerts control over the curve; the curved penis is just a reflection of plaque activity – good or bad.  A smaller plaque can create a larger curve if it is in the wrong place or is pulling or pushing in some strange way. It might make you feel sick to see your curve get worse, but ignore the curve and keep checking the condition of the Peyronie’s disease  plaque.  How do you check your plaque?  Go to review information about  my book, at Peyronie’s Disease Handbook

    Whenever someone sends me an email reporting that he is seeing improvement in his plaque or bent penis, I warn him that it will not initially last very long and that his problem will surely return for a short while.  I can almost guarantee this pattern.  Come to expect it; count on it.  It is just the way it goes, so do not be discouraged or disappointed when it happens.  In a short time, you will see the pattern develop that will tell you that good things are finally happening.  Just stay with it.

    How long it takes for the improvement to become permanent is also variable (just like everything about Peyronie’s disease).  Once you get your plan fine-tuned and working well for you, most of the time it takes 6-12 months or more for the progress to level off and become as good as it is going to be.  That does not mean that in 6-12 months or so you will be cured or completely well.  It just means you will be as good as you are going to be, in spite of your best effort.

    Peyronie’s disease treatment: changes to look for

    Know what to look for in early Peyronie’s treatment

    This post is about an interesting question I am asked from time to time about Peyronie’s disease treatment.  I thought it might be of interest to you.  The question is asked something like this, “When people finally get some positive changes in their Peyronie’s disease, how does it usually show up?  What usually happens first?  I want to know what I can expect, although I know we are all different.”

    Well, usually – not always – as a man continues in a sufficiently large and aggressively applied Peyronie’s disease treatment plan from PDI, he will notice at first some small and TEMPORARY changes in the size and density of his scar.  The temporary nature of the change does not last long.  As treatment continues the changes and improvement become permanent.  Usually the scar itself will change before there is a noticeable change in the Peyronie’s curved penis or his ability to develop an erection.  This scar change will take place maybe during months 2-6 of the treatment cycle, although I have worked with men who see changes in the scar after just a few weeks of a PDI plan.  This fast response is the exception and not the rule, so do not plan on that kind of response although it does happen.

    The initial and temporary improvement in the Peyronies plaque or scar will not last very long, maybe just a few days or so, and then it will often go back to how it was before – maybe even worse.  I wish I could say why this happens – it just does. Soon a pattern will develop in which there is improvement, regression, improvement, regression, back and forth, etc.  What happens over time is that you will notice that the amount of improvement will be greater than the regression, and the improvement will last longer than the regression.  You will likely see the pattern shifting slowly in favor of improvement – it will last longer and it will be greater than the regression.  Just like the stock market – it goes up and it goes down – but the general trend and pattern is that it slowly comes gets better.  This is how I have seen most every case of Peyronie’s disease improve.

    Just as the Peyronie’s plaque changes, a little while later it is common to see a change in the curvature. The initial change in the penis curvature is not always improvement, however.  My curve worsened just after my scar showed some real strong progress for the first time.  I kept in mind that the Peyronies plaque was getting better, so I did not let the change in the curve upset me.  I kept working to reduce the scars I had and in time the curve I had also eventually improved.    See Peyronie’s picture of curved penis.

    Peyronie’s plaque and pick-up-sticks

    Ever play “pick-up-sticks” as a kid?   With the complex interplay of sticks lying across each other, removing one stick makes three or four other sticks shift a bit.  I think the same happens in Peyronie’s disease.

    How many plaques or scars do you have?  If more than one, then the dynamics are made even more complicated.  If you have only one scar (kind of unusual) then you have one scar that could be influencing 2-3-4 different planes of connective tissue within the corpora cavernosa of the penis that it is attached to.  It is not difficult to understand that if a part of a scar is changing it could cause alteration of the tensions and angles of pull – as the scar is INCREASING or DECREASING in size – that could cause a change in the curve – to make it INITIALLY better or worse.  So in this sense, an increase in your curve is only seen as a bad thing if you know FOR A FACT that your scar(s) are increasing in size, shape or density. Over time, as the plaque continues to soften and reduce in size, and as the internal pull and tension created by these plaque begins to normalize, the curve should begin to straighten.  Continue monitoring yourself as you work aggressively, and you should see this positive pattern of recovery play out for you.

    A worsening of the curve is acceptable if the plaque is improving.  As far as treating your condition and monitoring progress, the condition of the Peyronie’s plaque is far more important to monitor than the curve; plaque changes size, shape and density characteristics, and even seem to move, and so the plaque or scar tissue exerts control over the curve; the curved penis is just a reflection of plaque activity – good or bad.  A smaller plaque can create a larger curve if it is in the wrong place or is pulling or pushing in some strange way. It might make you feel sick to say “My penis is curved!”, but ignore the curve and keep checking the condition of the Peyronie’s disease  plaque.  How do you check your plaque?  Go to my book, “Peyronie’s Disease Handbook” on the PDI website,  to review information about the Peyronie’s Disease Handbook.

    Whenever someone sends me an email reporting that he is seeing improvement in his plaque or bent penis, I warn him that it will not initially last very long and that his problem will surely return for a short while.  I can almost guarantee this pattern.  Come to expect it; count on it.  It is just the way it goes, so do not be discouraged or disappointed when it happens.  In a short time, you will see the pattern develop that will tell you that good things are finally happening.  Just stay with it.

    How long it takes for the improvement to become permanent is also variable (just like everything about Peyronie’s disease).  Once you get your plan fine-tuned and working well for you, most of the time it takes 6-12 months or more for the progress to level off and become as good as it is going to be.  That does not mean that in 6-12 months or so you will be cured or completely well.  It just means you will be as good as you are going to be, in spite of your best effort.   For some men it is complete recovery and full return to normal, and for other men it is a variable percent of improvement.

    No one can accurately anticipate or tell what level of improvement will happen even after an intense effort of Peyronie’s disease treatment.  Some of the worse cases make the most recovery, and some of the mildest problems improve the least.  You just have to do your best and do all that you can to regain your life in the best way you can.

    If you want to know more about what you might be experiencing right now with your condition, let me know.  Ask a question on the blog, and I will be happy to explain what I can to you.   TRH

    Peyronie's Disease Treatment Philosophy – General Comments

    The Peyronie’s Disease Institute treatment philosophy for dealing with Peyronie’s disease is not accepted within the medical community. You should know the PDI opinions and Peyronie’s disease treatment philosophy are not current mainstream medical thinking, although PDI has assisted a dozen or more MDs with their Peyronies problem in the last few years.

    The Peyronie’s Disease Institute philosophy for Peyronie’s treatment is different from standard medical thinking in two fundamental ways.

    1. PDI recommends using mainstream Alternative Medicine therapy products (vitamin E, copper copper, DMSO, enzymes, etc.), and procedures like a special gentle manual penis stretching technique we have developed, and acupuncture). These are recommended even though they have not fulfilled the testing standards usually required of medication.

    2. PDI has found after seven years of review and research that taking multiple therapies, all at the same time, in sufficient quantities as described on its website that it often stimulates or supports some degree of improved ability to heal and repair the famous Peyronie’s plaque or scar. The scientific term for this phenomenon is “synergy”.

    The specific therapy products used by PDI are well known and generally accepted as important, and often essential, for health and well being, such as vitamin E, MSM, acetyl-L-carnitine, etc. However, what is unique is that PDI advocates these therapy products are used in combination and in significant number for maximum potential effect and benefit. This synergistic concept of therapy used by PDI to treat PD takes advantage of the affect of synergy – a concept that is very well known in medical practice. Synergy is the ability of two or more substances to work together to produce a total effect greater than what each individual therapy could produce by itself. 

    This Peyronie’s disease treatment concept is based on simple observations about this problem:

    · Why do some men completely recover from Peyronie’s disease without treatment? You know, this happens in about half of the case.

    · Why do some men get worse and need surgery, no matter what treatment they try?

    · If the Peyronie’s plaque is similar to scars like I have on other parts of my body, why does it seem to change so much – not only the size, shape, and density of the scar, but also the location?

    · If it’s actually the same problem among all the men who have it, why does Peyronies vary so much from one man to the next?

    · What’s the difference between the two groups of men whose Peyronie’s disease goes away on its own, and the other in which it only gets worse no matter what they do for it?

    · What is the fundamental difference between these two groups of different responses?

    · How can I join the group that repairs and eliminates the Peyronie’s plaque and reverses the bent penis of PD?

    Certainly , no one has complete or easy answers to this questions – yet. However, I think it makes perfect sense that the man whose Peyronie’s disease simply goes away on its own has a better healing capacity, than another man whose PD never improves. It cannot be a mater of luck; nature is just not that way. It is my opinion that you can increase your healing capacity and become healthier in some yet undetermined way so you are able to heal your Peyronie’s scar and reverse your Peyronie’s bend to the best of your ability.

    The fact that some men are able to recover better than others, must mean there is variable − not static − capacity to healing and repair among men. Common sense and generally accepted knowledge about health, nutrition, and the healing process offers you and I the foundation for a treatment concept and philosophy that should improve your chances to recover from Peyronie’s disease better than if you did nothing to enhance your ability to heal. It is really as simple and direct as that.  The Peyronie’s plaque found within and on the tunica albuginea can be seen as an expression or extension of the overall health and healing potential of the body in which it occurs. Similar to an ulcer, a Peyronie’s plaque or scar can be thought of as the result of abnormal body chemistry and physiology. As such, treatment of Peyronie’s disease should attempt to improve that distressed or abnormal chemistry and physiology of the penile tissue in which the plaque is found.

    All therapy products, nutrients, techniques and ideas presented by PDI are all directly or indirectly intended to improve the chemistry and physiology of the body in general and plaque elimination in the tunica specifically. The end result of this effort should be a healthier person with healthier tissue that can heal better. That is the reason all Peyronie’s therapy items are selected on the basis of their potential to improve or normalize the chemistry and physiology of the tunica of the penis and the foreign plaque material.

    This Peyronie’s treatment philosophy is not offered as though we have an absolute Peyronie’s cure, not at all.   While we have a high success rate, it is not an absolute cure in that sense. It is merely presented as a way to treat the man who has Peyronie’s disease, because  we all know this happens in 50% of the cases – so it can be done, and it is being done.  PDI is merely offering a way to increase your potential to join the ranks of the men whose Peyronie’s plaque is healed naturally.  The only difference is that you are doing specific things in a deliberate and methodical manner to heal yourself better than you did the first time around.

    Peyronie’s Disease Institute adopts the judgment of Mayo Clinic concerning Peyronie’s disease when it stated. ”early stage disease [of Peyronie’s disease] is reputed to respond better than well-established plaques, an early trial of inexpensive, safe and well-tolerated oral therapy is often initially recommended. … With advances in the molecular biology of inflammation and wound healing, the management and understanding of this frustrating disease will no doubt improve.”

    With this statement in mind, I strongly recommend that any man, in any stage of Peyronie’s disease – no matter how chronic or advanced – should at least investigate the use of synergy created by the combination of several simultaneous non-invasive treatment measures selected on the basis of the best understanding of your problem and the information that is available to you. Peyronie’s disease treatment is variable from one man to the next. Because the Alternative Medicine therapies used in Peyronie’s disease treatment are intended not to treat the disease but to support and strengthen the man who has the problem, so he can heal and repair it to the best of his ability.  Since we are all different, each man must approach his own search for a Peyronies cure on an individual basis.

    When you look at the different therapy products on PDI website, realize that they are intended to increase your ability to heal and repair PD, just as it naturally and spontaneously happens in 50% of the men who develop this condition.   Keeping this in mind should change the way you look not only at Peyronie’s disease, but also the way that you consider your relationship to the problem and how you hope to eventually overcome it.

    Peyronie's Disease Institute Manual Penis Stretching Method

    Curved penis manual stretching method

    A few days ago a man asked me about Peyronie’s treatment using the Peyronie’s Disease Institute Manual Penis Stretching Method.  He is one of those who has been using a Peyronie’s treatment plan from PDI for a few months, with only slight success at this point, and added the stretching program to his plan in early October so he could get faster results.   He said he thinks there has been some small change in his Peyronie’s plaque and curvature, but wants to do more with the stretching concept. So he described how he is doing his Peyronies stretching, and asked my advice.

    What disturbed me was that, because he spends many hours a day at his computer, he said he stretches his penis curvature while working on his computer.  I advised him not to do this.  If you carefully listen and watch the penis stretching video you will see that light touch and gentle stretching are continuously emphasized throughout the video program.  It is necessary to constantly think and pay attention to what you are doing so that this is done correctly.  You must pay attention to the immediate response of the tissue to the gentle stretching that is being applied.  In order to be really effective as every man would want it to be, this kind of Peyronies treatment is not something you do while multitasking.

    For successful Peyronie’s treatment, and to reduce the Peyronie’s disease plaque with manual stretching, you must have your mind on what you are doing.  Set some time aside a few times a day, at least 15 minutes each time, to stretch the plaque or scar material.  If you can find more time than 15 minutes, great.  Some men tell me they spend over an hour at a time while watching TV – now that is the kind of multitasking that will work in a Peyronies treatment plan.

    To learn the PDI manual penis stretching method, it must be demonstrated; it does not lend itself well to written or oral instructions.  If you want to know more about this process, and see some still pictures of what this stretching Peyronies treatment looks like, and a 30 second YouTube video that shows some clips from the actual penis stretching CD, go to Peyronie’s manual penis stretching

    Of course, men with Peyronie’s disease know about the dangers of mechanical penis stretchers, since this site has written about this many times.

    Peyronie’s Disease Treatment with DMSO

    DMSO is a wide based Peyronie’s treatment

    Dimethyl sulfoxide (DMSO) was first synthesized in Germany in 1866.  Since then it has been available as a pulp-industry by-product for many years. Its principle use is currently that of an industrial solvent. While it is in use in medical and surgical treatment, it can be used in DMSO Peyronie’s therapy.

    In 1964 Dr. Stanley W. Jacob and others at the University of Oregon Medical School were the first to describe the remarkable medicinal properties of DMSO.  In this first work with DMSO they applied it to intact human skin, and discovered it penetrates rapidly and produces a wide range of pharmacologic actions.  Some of these are anti-inflammation properties, local analgesia, stopping bacterial growth in it presence, increased renal function to reduce edema, a carrier action with drugs it is coupled with, softening of collagen (the primary component of the Peyronie’s disease plaque), nonspecific enhancement of immunity, dilatation of blood vessels, and reduction of blood platelet adhesion.  As a result, DMSO has been used widely to treat various conditions (arthritis and bursitis, acute and chronic musculoskeletal trauma, scleroderma, chronic urogenital disorders, and unresponsive postoperative pain syndromes). To date, little to no local or systemic toxicity or tissue destruction has been noted in humans when DMSO is administered.

    Of special interest in Peyronie’s disease treatment, when normal tissue is injured or deteriorates for any reason, the damaged tissue naturally produces chemicals called “free radicals.”  It just so happens that DMSO is a potent scavenger of these radicals, maintaining the normal integrity of cells and tissues. These free radicals exert further harm to the damaged or aging cells, and thus prevent or slow the healing process.  Using DMSO in the treatment of Peyronie’s disease seems to make sense because it can be applied locally over the superficial surface of the plaque region.  Not only that, but it can be used to bring in other therapies directly into that same area – a double benefit. DMSO has been called “the most controversial therapeutic advance of modern times.”  However, the 40 year controversy since it first made medical headlines seems to be bureaucratic and economic, rather than scientific. More than 10,000 articles on the biologic actions of DMSO have been reported in the scientific literature, along with 30,000 articles on the chemistry of DMSO. These reports and studies strongly support the contention that DMSO is a truly significant new therapeutic principle.

    Currently, DMSO is a respected and approved pharmaceutical agent in more than 125 countries, but not the U.S. In 1970, the FDA approved DMSO for the treatment of musculoskeletal disorders in dogs and horses. Many veterinarians consider DMSO to be the most valuable therapeutic substance in their armamentarium.  Later, in 1978, DMSO was given FDA approval as a therapy for interstitial cystitis, a painful and disabling urinary bladder inflammation.

    In many ways, DMSO is the “aspirin” of our time. If aspirin had been introduced in 1963, as was DMSO, with its multiple beneficial therapeutic properties, aspirin surely would have been similarly restricted.

    DMSO became prescriptive for humans in the USSR in 1971, in therapy of various musculoskeletal problems. Dr. V. Balabanova of the Moscow Institute of Rheumatology estimates that approximately 50 percent of the Russian population who have arthritis will receive DMSO as part of their therapy. There are more than one hundred articles in the world’s literature relating to DMSO and arthritis. This widespread and common use is based on the well-established pharmacologic actions of DMSO to reduce pain, reduce inflammation, soften scar tissue and contracted fibrous tissue elements, remove free radicals, increase circulation and stimulate healing.  No one with Peyronie’s disease can deny the value of these functions in the repair of the Peyronies plaque.

    Based on research from around the world, DMSO has proven to be an effective treatment for many illnesses that otherwise have no known therapy. DMSO is safer, far less expensive, and at least as effective for a variety of problems for which the medical community is presently using other, less effective, and more costly treatments. In 1972 the National Academy of Sciences evaluated the scientific data on DMSO and determined it was a least as effective as other currently approved treatments for three musculoskeletal inflammatory human conditions. Yet, it has not been given FDA approval for these same conditions. Certainly, one of the most important questions about any new medicinal therapy is safety.  The only potentially serious side effect is the occasional patient who is allergic.  In Peyronie’s disease treatment, this is reduced simply by the small area to which DMSO is applied and the administration of topical vitamin E and urea with the PMD-DOMSO formulation created by PDI.

    A careful review of the published literature on DMSO shows there is not a single death which can be  definitely attributed to this agent. Since it first appeared in the mid-1960s, hundreds of millions of treatments have been applied worldwide, showing that DMSO is a substance of extraordinary low tissue toxicity. At that time the FDA had received data submitted by approximately 1,500 U.S. physicians concerning over 100,000 DMSO applications, all showing safety and effectiveness. The pharmaceutical companies submitting this positive data were Squibb, Merck, and Syntex, all who would have suffered economic harm if this inexpensive therapy was made more popular and readily available.  With the withdrawal of their support, all further U.S. DMSO research and documentation of effectiveness has stopped.  Thus, the large drug companies blocked further interest or use in a safe, easy, effective and inexpensive substance that could help stop the progression of Peyronie’s disease, so they could develop drugs in which their profit potential was much greater.

    Much of the resistance to the use of DMSO in Peyronie’s disease can be thought to be more political and economic, than scientific.  For these reasons, the Peyronie’s Disease Institute has used DMSO in its therapy program from the onset.   TRH