What about the use of emu oil for treatment of Peyronie's disease?


I read about DMSO’s ability to carry into the skin. Emu oil I have heard also does this. Do you have thoughts on this? I wonder which would be better/more effective? Emu oil comes from a bird’s skin and DMSO is a wood-processing by-product. Neither one sound very appealing to me but the bird skin at least seems a bit more natural.



Most medical usage of emu oil is for the topical treatment of skin conditions (hives, shingles, psoriasis, etc.)  and other problems (arthritis,weight loss, earaches, flu symptoms, etc.)  

Little serious investigation has been done about the carrier ability of emu oil to bring chemicals and drugs it is combined with into the body, as DMSO does.  

from my experience i have found that many men who have attempted to use emu oil in this way to treat their Peyronie’s disease and usually disappointed, and only make progress when they switch over to using DMSO as a carrier.  TRH

How often and for how long do you recommend moist heat for the Peyronie's scars?

How often and for how long do you recommend moist heat for the Peyronies scars?   Thanks, Roger

Greetings Roger, 

Use moist heat prior to the topical or external therapy (DMSO application or especially manual stretching technique) .  For this reason it will be more efficient to perform these together as a group so you do not have to do it several times a day. 

However, it is probably not advisable to use moist heart immediately prior to Genesen therapy since it would easily throw off any level of tissue sensitivity and make it falsely look like EVERY place you touch with the pens are active – when this is not actually true.  You would wind up wasting your time by treating points that did not need it although they appeared to need it.

5-10 minutes is a good time range to apply the heat.  You are only attempting to draw blood to the area of the shaft, and it does not take that long to dilate the blood vessels for that purpose; you are not poaching meat.   TRH  

How long to wait between using DMSO and intercourse?

Dr. Herazy,

Thank you for your time a moment ago when we spoke on the phone. If I may impose upon you for one last question: How long between application of DMSO to the shaft of the penis and sexual engagement should there be to avoid "sharing" the DMSO with your partner? Or, is this not something that one needs to be concerned with due to the benign nature of the substance?




Greetings Foster,

If you read on PDI website about DMSO you will learn that about 7-8 minutes after application for Peyronies disease treatment all DMSO is essentially gone from the surface of the skin and is being chemically taken deeper into the tissue; actually most is gone in 5 minutes or so.  Nonetheless, I suggest washing the shaft prior to intercourse because the penis shaft is covered with common skin as is the majority of the body, but inside the vagina is found a mucus membrane layer of tissue, similar to the inside of mouth or sinus passages.  This thin and delicate tissue might respond differently than the rest of the body – better safe than sorry.   TRH

Any suggestions for using a DMSO "wrap"?

Hi Dr.Herazy my question is about using "wraps" im only using DMSO/Vitamin E/Castor oil wrap, im just curious what is the best way to leave a cloth/wrap that a guy uses to keep it in place, i tried using duct tape to keep the cloth on my penis it works but the thing is i can't keep it in one place, kinda loose on my penis so i feel like my penis isn't getting the complete benefit if i were to find a tighter wrap or bandage somewhere at or store… because i can't keep the cloth from sliding off, so i would like to know is there something i can buy like at Walmart or something im thinking of a way to keep the cloth adhere to the penis skin so i'll know the wrap with the 2 oils are getting into the plaque online some websites say to use a rubber band to keep it in place but that frightens me, so what is the best way and a place i can find a wrap that can adhere too the skin so it isn't so loose wrapped around the penis. It's so frustrating trying to use a DMSO wrap but can't keep it in place… any suggestions for people going this route?


Stop what you are doing for two reasons:

  • What you are doing is potentially dangerous – by applying prolonged compression to the penis with rubber bands or duct tape you cannot help but cut off blood circulation, and this is a good way to develop Peyronie's disease.  One of the proposed mechanisms of developing PD is by micro-reduction of blood circulation, and this is what you are doing.  Just like we are warned to release a tourniquet for a minute every ten minutes, you do not want to cut off blood circulation for too long to any part of the body.  Many men develop PD from using a "cock ring."  Your method of holding the wrap in place could easily do the same thing to you.
  • How you are using DMSO does not make sense – DMSO works in just a few minutes and does need to held in place for hours.  DMSO is a great PD therapy, but it must be used correctly and safely.   When you buy DMSO form this website you will be given complete instructions how to use it properly and without harm to you.  There is absolutely no reason to leave a "wrap" in place for hours on end, because nothing happens under that wrap after a very short time.  Your DMSO does its maximum work in the 1st seven minutes or so after you apply it to the skin, and after that not much happens. Using DMSO is not like sunbathing, when the longer you do it the more will happen.   If you feel a sensation of warmth, it is only because you have your shaft wrapped in a cloth that is covered by plastic.    

It is really amazing what dangerous and upside down thinking I see on the Peyronie's disease forums from people who promote ideas without knowing  what they are doing.  I think you were given some bad information.    

You are apparently, for some reason you did not explain, using a modification of the Thacker's formula.  If you intended to use the Thacker formula you were given false information about that, also.

There is a better way to use DMSO, just go to the PDI website to read how it should be done.   

How often should a person with Peyronies use DMSO?

How often should a person with Peyronies use DMSO?  Can you use it daily with other topicals?   Will the stuff you put on after DMSO still go on?   Online it says put to put DMSO on LAST.  What if you put the DMSO on first is it still effective?


Based on the basic nature of your questions about DMSO (how often to use it; combining it with other topical therapies; frequency of application) I have the sense that you have not gotten your DMSO from PDI.  Anyone who buys from PDI knows the answers to these questions and more.  PDI provides specific information and details for correct use with all the PD therapy products we sell.  We help you every step of your journey so you get the best results you can; you would not have these questions if you were dealing with PDI.  And this brings me to my biggest concern about you…

Some men make the mistake of using the highest concentration OF DMSO they can find, thinking that stronger is better and it is not.  You cannot use effectively use a high concentration DMSO for PD treatment very long without it quickly irritating the delicate skin of the penis.   This is why PDI offers the PMD DMSO brand of DMSO that was formulated in cooperation with Stanley Jacobs, MD, the man who in the late 1950s did the first medical DMSO research on humans.   Our DMSO formula has the best concentration for PD treatment, and it also contains PABA, MSM and urea for added benefit.  No other DMSO product is made specifically for Peyronies treatment but our PMD DMSO. 

Lastly, I must mention that you need to be very careful what you combine with DMSO when it is on your skin.  You mention applying "stuff" with DMSO.  This concerns me.  I have had contact with many men who decided to experiment by applying all types of chemicals along with DMSO over their PD scars.  Some men have crushed up and diluted drugs, applied solvents, slats and hormones and added DMSO to their experiments.   All of this can be extremely dangerous and counterproductive.  Please do not experiment with DMSO in this way.     

Now that I have had my say about DMSO in general, here are the answers to your questions:

DMSO can be used up to three times daily. 

It can be used daily with other appropriate safe topical therapies. 

It is best to apply DMSO last if you are also using other topical therapies; if you apply DMSO first there will still be reduced transfer of those topical therapies you applied first.     

Do you think this is a bad idea?

Can you tell me what you think of using DMSO and possibly vinegar since it contains acetic acid, i used it and it didn't hurt but the mixture got very warm to almost hot, and it wrinkles the skin, i got this on a website… Wikipedia and other sources say….Diluted acetic acid is also used in physical therapy to break up nodules of scar tissue via iontophoresis. So can't you use dmso to deliver the acetic acid in vinegar similar to iontophoresis to break up peyronie's plaque? Do you think this is a bad idea to try?



Yes, I think this is a bad idea.  You got lucky that you only felt a hot sensation and that it just wrinkled your tissue.  I suppose had you left the vinegar on longer, or used it a second time, or in some other way increased your exposure to it, you would have probably developed a deep and serious burn of the penile tissue.  Do you know what would have been the likely result of a burn-injury to the deeper tissue of the penis for someone who already has Peyronie's disease?  More Peyronie's disease. 

Acetic acid of vinegar is a dangerous acid that will affect different tissues of the body in a variety of ways. The thin tissue of the entire genital region is unusually vulnerable to a burn injury caused by acetic acid.  When it is combined with DMSO the damage can be even more severe. 

Please do not do use vinegar again this way for your Peyronie's disease.  TRH  

Does DMSO cause infertility?

Does DMSO have any long term side effects i.e does it affect fertility in any way?



There are no reports or studies that connect the use of DMSO and infertility in humans whether related to Peyronie's treatment or other health problems.  There are reports of veterinary medicine using DMSO to treat infertility in horses and dogs related to fibrosis of tissues that are a part of the reproductive system.   TRH

What is the difference between DMSO in gel and liquid form?

Online the PDI site says your DMSO LIQUID is more effective than the GEL. I fear the topicals I use won't penetrate as deeply if i were to use the liquid? How is effectiveness different?  Thank you.


Both the gel and liquid format are effective in their own way, depending on what you want to accomplish. Read DMSO in Peyronie's Therapy.

We have determined that the DMSO liquid penetrates faster than the gel, but not only a little faster.   And we have determined that the DMSO gel penetrates deeper and carries more therapy agents with it.  For this important reason in 2009 PDI converted both the Dusa Sal DMSO (Dupuytren contracture) and PMD DMSO (Peyronie's disease) products to being made with a gel base.  It makes sense to sacrifice a little speed of penetration to gain depth and amount of therapy delivered to the tissue involved.   TRH

What are the best two choices to treat Peyronies?

Hi again.  Between PMD DMSO, Super CP Serum and Unique E oil what are the best two choices to treat Peyronies?   How do I go about using them?    Monty


Greetings Monty, 

You are asking a question no one can answer.  You must apply these therapies to yourself to learn exactly which is most effective for you.  The PMD DMSO is always used because it will bring the other two deep into the tissue; therefore the choice is between the Super CP Serum and the Callisto oil.  Because of the low cost, most men use all three of these.

From your question it is obvious you are trying to approach Peyronies treatment from a minimal standpoint, and this is doomed for failure.  You must treat PD treatment aggressively and with a broad approach.   Also, using only external therapies (PMD DMSO, Super CP Serum and Unique E oil) only is also not a good idea; you must also use internal therapies (vitamin E, vitamin C, MSM, PABA, acetyl-L-carnitine, etc.). 

How any or all of them is actually used is provided when you receive your order.  You are given everything you need to be successful.  TRH



Where is DMSO gel applied?

Dr. Herazy,

My order arrived last week, and today I started the treatment.  I'm very upbeat that I made the right decision. I have carefully reviewed all the documentation and explanations that came with my order.  It is very impressive how well you prepare your customers to work with their Peyronie's treatment products. 

The one item that I'm most confused about is the PMD DMSO gel.  Exactly where is this gel applied?  My instructions say that the topical therapies should be applied over or on top of the location of the Peyronie's plaque or scar. I do not have any scar. I don't have a problem shaving as described but I do not have a scar either on the part to be shaved or the penis. Or, when they mention scar, do they mean the part of the penis that is abnormally hard?  Please advise.  Randy


Greetings Randy,

Actually, if you have Peyronie's disease you do have a plaque or scar.   However, the scar is not external or superficial, it is internal and below the surface. It is located under the skin surface and within the tissue of penis called the tunica albuginea.  The scar or plaque is not visible from the surface; you cannot see it.  The closest you can come to actually seeing it is if the scar is so large and thick that it raises or elevates the penile skin above it and you can see the raised lump of tissue because of the large scar below the surface.  

In order to be successful you really want to get to the point that you know the size, shape, density, and surface quality of your scar(s). If this is a new concept to you, I suggest you get the 1st book I wrote “Peyronie’s Disease Handbook.” It will help you immensely.

Scar location is sometimes a complicated topic, especially in the case of multiple scars or plaques. You can expect to find at least one scar at the point of greatest concavity of your distortion. Again, this is a topic of such concern and importance that you really should get at least that one book so that you know what you are doing in regard to monitoring your scar. The physical change in your scar is going to guide your therapy; it will direct you to the best use of your therapy plan. to assist you with this subject, please go to Difficulty Finding the Peyronie's Plaque.

To answer your question about where to apply the DMSO gel and related external therapies, they should be applied directly over the area of Peyronie's plaque or scar.  You do not need to apply these external therapies to the entire shaft, unless, of course, you have a wide spread pattern of scars over most of the penis.  TRH    

How do I get the DMSO gel to stay on?

How do I get the DMSO gel to stay on?  It's so viscous it won't spread out on it's own.

Tom. U.

Greetings Tom,

Never been asked that question before. My guess is that because DMSO “freezes” somewhere around 62 (?) degrees Fahrenheit, that this might be your problem. If the place where you are keeping it is rather cool, it might simply be close to turning to a solid.

I suggest you simply place it in a container of warm – not hot – water to allow it to come to its normal liquid state. The DMSO gel should have the consistency of  liquid hair shampoo. Be sure that the DMSO is the last thing you apply to the area if you are also using Super CP Serum and Unique-E oil to the shaft.   TRH

How to use Thatcher's formula for Peyronie's disease?

Doctor, I have one question. How does someone use Thatcher’s Formula (DMSO + Castor Oil + copper) for Peyronie’s disease? Over the last few months I have researched various PD topics I have found a few random posts about this formula and how to apply it using flannel and warm heat…if you have any more specific information, would you kindly pass it along?  Thank you for your time and information, Bill

Greetings Bill,

Yes, I know about using Thacker’s formula.  Thacker’s formula has bounced around a lot for many years in Peyronie’s disease discussion groups, and has achieved something close to cult notoriety.

The first thing you should know about Thacker’s formula is that it does not contain copper.   It contains, DMSO, castor oil and apple cider vinegar.  It is essential that you do not use this therapy, or any other, based upon what you pick up here and there on the various Peyronie’s forums where many untested and untrue ideas are promoted – like the notion that Thacker’s formula contains copper.

My suggestion to you is to first use a well balanced and aggressive Peyronie’s therapy plan such as you see on the PDI website, while you carefully monitor your scar for changes in size, shape, density and surface features to give evidence to your progress.   Our PDI therapy plans have been used since 2002 with success and are based on reasonable science and positive research findings.  This makes more sense to me than using Thacker’s formula by itself.   I would agree that you should consider using Thacker’s formula along with other therapies in a combined effort, just as we recommend combining other PD therapies for best effect.

Please let me know how I can help you during your therapy effort.  TRH

Peyronie’s Disease Treatment and Heat

Hot packs are a good Peyronie’s treatment

Even though you follow a good Peyronie’s disease treatment program based  current scientific knowledge of biochemistry and physiology, many men overlook a very effective therapy that is essentially free.

Heat – moist heat – can be incorporated in every Alternative Medicine Peyronies plan, especially those that use external therapies.  I am currently coaching a few MDs about treatment of their Peyronie’s disease plaque and fibrin that it contains; I can see a few of them roll their eyes when they read this.  Imagine, using moist heat for Peyronie’s disease – isn’t that cute.  Many people would probably not even consider using because it seems too low-tech, too simple, too basic, too dumb, to be of any  value.  Yet, I used it and so do a lot of the men I work with about their treatment plans.  Moist heat should be an important part of your Peyronie’s disease treatment plan.

Applying moist heat before and after using the combination of DMSO, topical vitamin E, and the copper peptide serum makes a lot of sense.  The heat dilates the blood vessels of the area and causes greater absorption of these three therapies into the tissue of the Peyronies plaque. Use moist heat on you penis if you are going to be doing any kind of external therapy.  For that matter, even if all you are doing are internal therapies of vitamins, minerals and enzymes, moist heat is still a good inexpensive therapy to do every day, all by itself.

Moist heat applied before other therapies (DMSO, copper peptides, vitamin E oil) will give them an extra advantage.  If you precede most any external therapy (or sexual activity) with moist heat you will bring extra blood to the genital area.  The additional blood flow and increased lymphatic drainage that occurs will allow other therapies to penetrate deeper and expand the tissue more fully.   In addition, you can also apply more moist heat after any or all of your therapies.  Moist heat will assure a better therapeutic response.

An element of potential danger is present when you apply heat to the delicate tissue of the genital area.  You must be very careful the heat is not too great and that you do not fall asleep with the heat being applied.  If you have a fair complexion, or have a history of burning easily, take extra steps to protect yourself from injury.  It is important that you check your skin frequently to assure you are not burning yourself.  If you use common sense and care with the process, there should be little problem.

Here is an excerpt from my book, “Peyronie’s Disease Handbook”:

“A hot shower is generally not effective because the heat is applied in such a broad area that much additional blood cannot be sent over the entire body surface.  You will not experience the degree of increased blood flow and lymphatic drainage as when the heat is focused to a smaller and more specific area.

To do this properly, prepare three towels:

The first is used to cover the surface you will be sitting or laying on.

The second should be a large clean towel.  Soak it water as hot as you can stand to handle.  Wring the towel out as completely as you can, so that it is not dripping excess water.  Lie down in a comfortable position on top of the dry towel.  Apply the large hot moist towel to the genital area for 5-15 minutes, with special attention to covering and wrapping specifically around the penis, being careful not to burn yourself.

The third is a towel to cover and insulate the moist towel to keep it as hot as you can stand, for as long as possible.

The first time you do this, PLEASE check yourself after the first few minutes and check yourself again five minutes after the first check, to assure that you are not burning your tender genital tissue.  If it should happen, because that is the nature of accidents, use:

1.      Ice pack to the area for 20 minutes only, no more. After 20 minutes the response of the body to the ice changes, and the tissue begins to swell and favor retention of inflammatory by-products.   Do this twice the first day and then daily until you are no longer in pain.

2.      Neosporin topical ointment applied to the area of injury according to package instructions.  Keep the area clean and covered with sterile gauze.

3.      Aloe vera gel applied to the area will speed healing.

4.      Determine what you did wrong with the heat; don’t do it again, because you will be using moist heat again in a slightly different manner, as it is still a good thing to do.  Adjust and modify your technique so you will not burn yourself again.

At the conclusion of the moist heat application you should be nicely red – only.  You should not feel like you are sore to the touch after using the hot towel.  If possible, keep the hot moist towel in place while doing other therapy; apply moist heat while doing DMSO, copper peptide, and vitamin E Peyronie’s treatment, or soft tissue massage to the lower pelvis.

“As a very nice option, you can also simply use a hot water bottle wrapped with a moist towel to the genital when you go to bed, or simply put it in place if you are going to be sitting for a long time in front of the TV, your computer or even your car.  Or, you can even put a half or full cup of rice in an old sock, tie off the open end, and heat it in the microwave for a few minutes.  This is an easy and inexpensive way to make a handy reusable heating method for your problem area.  Every little bit helps.”

Do not underestimate the value of moist heat applied to the penis to speed up healing – it might seem old-fashioned, but it works wonders.  Do it!

Any questions about this post?  Ask your questions under the main heading of “Ask Dr. Herazy…”    TRH

Peyronie’s Disease Treatment with DMSO

DMSO is a wide based Peyronie’s treatment

Dimethyl sulfoxide (DMSO) was first synthesized in Germany in 1866.  Since then it has been available as a pulp-industry by-product for many years. Its principle use is currently that of an industrial solvent. While it is in use in medical and surgical treatment, it can be used in DMSO Peyronie’s therapy.

In 1964 Dr. Stanley W. Jacob and others at the University of Oregon Medical School were the first to describe the remarkable medicinal properties of DMSO.  In this first work with DMSO they applied it to intact human skin, and discovered it penetrates rapidly and produces a wide range of pharmacologic actions.  Some of these are anti-inflammation properties, local analgesia, stopping bacterial growth in it presence, increased renal function to reduce edema, a carrier action with drugs it is coupled with, softening of collagen (the primary component of the Peyronie’s disease plaque), nonspecific enhancement of immunity, dilatation of blood vessels, and reduction of blood platelet adhesion.  As a result, DMSO has been used widely to treat various conditions (arthritis and bursitis, acute and chronic musculoskeletal trauma, scleroderma, chronic urogenital disorders, and unresponsive postoperative pain syndromes). To date, little to no local or systemic toxicity or tissue destruction has been noted in humans when DMSO is administered.

Of special interest in Peyronie’s disease treatment, when normal tissue is injured or deteriorates for any reason, the damaged tissue naturally produces chemicals called “free radicals.”  It just so happens that DMSO is a potent scavenger of these radicals, maintaining the normal integrity of cells and tissues. These free radicals exert further harm to the damaged or aging cells, and thus prevent or slow the healing process.  Using DMSO in the treatment of Peyronie’s disease seems to make sense because it can be applied locally over the superficial surface of the plaque region.  Not only that, but it can be used to bring in other therapies directly into that same area – a double benefit. DMSO has been called “the most controversial therapeutic advance of modern times.”  However, the 40 year controversy since it first made medical headlines seems to be bureaucratic and economic, rather than scientific. More than 10,000 articles on the biologic actions of DMSO have been reported in the scientific literature, along with 30,000 articles on the chemistry of DMSO. These reports and studies strongly support the contention that DMSO is a truly significant new therapeutic principle.

Currently, DMSO is a respected and approved pharmaceutical agent in more than 125 countries, but not the U.S. In 1970, the FDA approved DMSO for the treatment of musculoskeletal disorders in dogs and horses. Many veterinarians consider DMSO to be the most valuable therapeutic substance in their armamentarium.  Later, in 1978, DMSO was given FDA approval as a therapy for interstitial cystitis, a painful and disabling urinary bladder inflammation.

In many ways, DMSO is the “aspirin” of our time. If aspirin had been introduced in 1963, as was DMSO, with its multiple beneficial therapeutic properties, aspirin surely would have been similarly restricted.

DMSO became prescriptive for humans in the USSR in 1971, in therapy of various musculoskeletal problems. Dr. V. Balabanova of the Moscow Institute of Rheumatology estimates that approximately 50 percent of the Russian population who have arthritis will receive DMSO as part of their therapy. There are more than one hundred articles in the world’s literature relating to DMSO and arthritis. This widespread and common use is based on the well-established pharmacologic actions of DMSO to reduce pain, reduce inflammation, soften scar tissue and contracted fibrous tissue elements, remove free radicals, increase circulation and stimulate healing.  No one with Peyronie’s disease can deny the value of these functions in the repair of the Peyronies plaque.

Based on research from around the world, DMSO has proven to be an effective treatment for many illnesses that otherwise have no known therapy. DMSO is safer, far less expensive, and at least as effective for a variety of problems for which the medical community is presently using other, less effective, and more costly treatments. In 1972 the National Academy of Sciences evaluated the scientific data on DMSO and determined it was a least as effective as other currently approved treatments for three musculoskeletal inflammatory human conditions. Yet, it has not been given FDA approval for these same conditions. Certainly, one of the most important questions about any new medicinal therapy is safety.  The only potentially serious side effect is the occasional patient who is allergic.  In Peyronie’s disease treatment, this is reduced simply by the small area to which DMSO is applied and the administration of topical vitamin E and urea with the PMD-DOMSO formulation created by PDI.

A careful review of the published literature on DMSO shows there is not a single death which can be  definitely attributed to this agent. Since it first appeared in the mid-1960s, hundreds of millions of treatments have been applied worldwide, showing that DMSO is a substance of extraordinary low tissue toxicity. At that time the FDA had received data submitted by approximately 1,500 U.S. physicians concerning over 100,000 DMSO applications, all showing safety and effectiveness. The pharmaceutical companies submitting this positive data were Squibb, Merck, and Syntex, all who would have suffered economic harm if this inexpensive therapy was made more popular and readily available.  With the withdrawal of their support, all further U.S. DMSO research and documentation of effectiveness has stopped.  Thus, the large drug companies blocked further interest or use in a safe, easy, effective and inexpensive substance that could help stop the progression of Peyronie’s disease, so they could develop drugs in which their profit potential was much greater.

Much of the resistance to the use of DMSO in Peyronie’s disease can be thought to be more political and economic, than scientific.  For these reasons, the Peyronie’s Disease Institute has used DMSO in its therapy program from the onset.   TRH